in spite of the fact that和Regardless of the fact that的意思基本上相同,都有"虽然/尽管；即使不管事实上如何"之意,二者可以互相代换，但前者用的较多。
例如:
Regardless of the fact that they speak different languages,engineers can communicate their ideas more clearly to others if they are able to sketch.
尽管工程师们说不同的语言,但如果他们会画草图,他们彼此就能很容易地交流思想.
Regardless of还可以这样用：Regardless of sth.
Regardless of+宾从．
例如：
Regardless of danger,he climbed the pagoda.他不顾危险地爬上了高塔.
I shall go regardless of the weather.无论天气好坏我都要去.
Regardless of how often I correct him,he always makes the same mistake.
不管我怎样经常告诫他,他总是犯同样的错误.
In spite of the fact that it is snowing,she is going out for a walk.
尽管正在下雪,她仍然要出去散步.
In spite of the fact that they are against it,we are going on doing it.
不顾他们反对,我们继续干下去.