作者：Ou H，et al.
译者：石家庄市妇幼保健院 刘静
译者简介: 女，石家庄市妇幼保健院保胎门诊主任，急诊科主任，大产科副主任，科教科副主任，医学博士，副主任医师，2015年作为访问学者赴美国杜兰大学医学院学习。2019年跟随中国北医三院“生殖免疫之父”刘湘源教授进修。擅长：复发性流产、病理妊娠、乙肝孕妇母婴阻断、异常产程处理、产钳术、胎头吸引术、催产和引产术、熟练掌握前置胎盘、胎盘早剥、妊娠期高血压疾病、妊娠期急性脂肪肝、肝内胆汁瘀积症、围产期心肌病、产后出血、羊水栓塞、胎儿宫内窘迫等产科危重症的抢救。获省市级科研成果奖励三项。发表SCI及核心期刊论文二十余篇。
【摘要】
目的: 探讨阿斯匹林、强的松、爱乐维三联疗法治疗不明原因复发性早孕的疗效。
方法:2013年1月1日至2016年12月31日，北京协和医院收治不明原因复发性流产妇女共353例，其中155例患者接受了血常规、尿常规和阴道拭子检查。根据治疗方案将155例患者分为两组，试验组89例(57.42%)，接受阿司匹林、强的松、爱乐维治疗；对照组66例接受口服叶酸治疗(42.58%)。12周时超声检查胎儿芽、胎心及颈部透明层厚度。可见胎芽、胎心、颈部半透明厚度<0.3 cm为治疗成功的指标。采用t检验和χ2试验分析和比较两组之间的差异, Logistic回归方法被用来分析数据,观察药物的作用。
结果:实验组治疗成功67例，成功率为83.75%(67/80)，对照组治疗成功33例，成功率为54.10%(33/61)。两组比较差异有统计学意义(P<0.05)。
结论: 与口服叶酸相比较，阿斯匹林、强的松、爱乐维三联疗法治疗不明原因复发性流产疗效更为显著。
附原文：
Abstract Objective: To investigate the effect of triple therapy with aspirin, prednisone and Elevit in patients with unexplained recurrent early pregnancy loss. Methods: From January 1, 2013 to December 31, 2016, a total of 353 women of childbearing age were enrolled in Peking Union Medical College Hospital, including blood, urine and vaginal swabs. One hundred and fifty-five patients were observed normal results of blood test, urine test and vaginal swabs. According to the treatment regimen, 155 patients were divided into two groups, 89 patients (57.42%) treated with (aspirin, prednisone, and Elevit) as experimental group, and the other 66 cases (42.58%) taking folic acid as control group. The fetal bud, fetal heart and neck hyaline layer thickness were examined by ultrasonography at 12 weeks. Visible fetal bud, fetal heart, and nuchal translucency thickness <0.3 cm were used as indicators of successful treatment. t test and χ(2) test were used to analyze and compare the statistical significance of the differences between the two groups of patients, and the Logistic method was used to analyze the data and observe the effect of medication. Results: There were 67 patients successfully treated in the experimental group, the successful rate was 83.75% (67/80), and 33 patients in the control group were successfully treated, the successful rate was 54.10% (33/61). There were significant statistical differences in two groups (P<0.05). Conclusion: The effect of triple therapy with aspirin, prednisone and Elevit in patients with unexplained recurrent early pregnancy loss is significant.
引自：
Ou H，et al.Effects of combination therapy with aspirin, prednisone, and Elevit in patients with unexplained recurrent early pregnancy loss。