题目

期刊

影响因子

发表日期

研究内容

Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics

PNAS

9.58

July, 2017

人胎盘组织细胞异质性

Dr.seq2: A quality control and analysis pipeline for parallel single cell transcriptome and epigenome data

Plos one

2.776

July, 2017

开发了单细胞数据QC的方法和分析pipeline

The Apostasia genome and the evolution of orchids

Nature

41.577

Sep, 2017

组装拟兰花基因组

Pulmonary alveolar type I cell population consists of two distinct subtypes that differ in cell fate

PNAS

9.58

Jan, 2018

研究人肺泡细胞的不同亚型

Draft genome of the Peruvian scallop Argopecten purpuratus

Gigascienc

7.267

Apr, 2018

组装扇贝基因组

Single-Cell RNA-Seq Reveals Dynamic Early Embryonic-like Programs during Chemical Reprogramming

Cell Stem Cell

21.464

July, 2018

研究在化合物诱导的重编程过程中，细胞所处的不同状态

The opium poppy genome and morphinan production

Science

37.205

Aug, 2018

组装了*粟罂**的基因组

Single-cell RNA-seq analysis maps the development of human fetal retina

bioRxiv

NA

Sep, 2018

研究人胚胎期视网膜细胞的发育

Draft genome of Glyptosternon maculatum, an endemic fish from Tibet Plateau

Gigascienc

7.267

Sep, 2018

组装藏鮡骨鱼的基因组

PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2

Neuron

14.403

Sep, 2018

研究脑组织的急性感染

Single-cell transcriptomics reveal that PD-1 mediates immune tolerance by regulating proliferation of regulatory T cells

Genome Medicine

8.898

Sep, 2018

研究小鼠Treg细胞在免疫耐受方面的功能

VASC: Dimension Reduction and Visualization of Single-cell RNA-seq Data by Deep Variational Autoencoder

Genomics, Proteomics & Bioinformatics

6.597

Dec, 2018

单细胞转录组数据分析方法的文章，解决基因dropout问题

Single-cell transcriptome provides novel insights into antler stem cells, a cell type capable of mammalian organ regeneration

Functional & Integrative Genomics

2.745

Jan, 2019

研究鹿角干细胞的再生

Comparative Analysis of Droplet-Based Ultra-High-Throughput Single-Cell RNA-Seq Systems

Molecular Cell

14.248

Jan, 2019

对比不同单细胞平台的优劣，包括10x， inDrop和Drop-seq

Single-cell transcriptomes reveal molecular specializations of neuronal cell types in the developing cerebellum

JMCB

4.671

Jan, 2019

研究小鼠小脑发育过程中的神经细胞类型，

Cell Fate Determining Molecular Switches and Signaling Pathway in Pax7-expressing Somitic Mesoderm

bioRxiv

NA

Jan, 2019

研究胚胎发育

The sequence and de novo assembly of hog deer genome

Scientific Data

5.929

Jan, 2019

组装豚鹿基因组

Defining multistep cell fate decision pathways during pancreatic development at single-cell resolution

The EMBO Journal

9.792

Feb, 2019

研究胚胎期小鼠胰腺细胞的发育，发现ERK pathway的活性对alpha和beta胰腺细胞的分化有重要作用

Resolving Cell Fate Decisions during Somatic Cell Reprogramming by Single-Cell RNA-Seq

Molecular Cell

14.248

Feb, 2019

在转录因子或化合物诱导的体细胞重编程过程中，对细胞命运决定起关键作用的转录因子

Cell–cell communication old mystery and new opportunity

Cell Biol Toxicol

5.097

Feb, 2019

单细胞Review

A component overlapping attribute clustering (COAC) algorithm for single-cell RNA sequencing data analysis and potential pathobiological implications

PLOS Computational Biology

4.428

Feb, 2019

数据分析文章，研究单细胞聚类方法

Single-cell RNA-seq of cultured human adipose-derived mesenchymal stem cells

Scientific Data

5.929

Feb, 2019

研究间充质干细胞的异质性，探索用于治疗疾病的潜力

Role of alternative polyadenylation dynamics in acute myeloid leukaemia at single-cell resolution

RNA Biology

5.216

Mar, 2019

研究AML白血病

A Single-Cell RNA Sequencing Profiles the Developmental Landscape of Arabidopsis Root

Molecular Plant

9.326

April, 2019

研究拟南芥根的异质性

SSCC: A Novel Computational Framework for Rapid and Accurate Clustering Large-scale Single Cell RNA-seq Data

Genomics, Proteomics & Bioinformatics

6.597

April, 2019

单细胞转录组数据分析方法，可以对大量细胞快速聚类

High-Order Correlation Integration for Single-Cell or Bulk RNA-seq Data Analysis

Frontiers in Genetics

3.517

April, 2019

单细胞转录数据分析方法，用于降噪和细胞聚类

Extensive exploration of T cell heterogeneity in cancers by single cell sequencing

Chinese Journal of Cancer Research

2.515

April, 2019

Review，介绍单细胞测序技术在研究肿瘤内部T细胞异质性中的应用

Gossypium barbadense and Gossypium hirsutum genomes provide insights into the origin and evolution of allotetraploid cotton

Nature Genetics

25.455

April, 2019

做棉花基因组的组装

Sing cell RNA-seq reveals cellular diversity and developmental characteristics of human infant retina

bioRxiv

NA

April, 2019

研究婴儿视网膜细胞的异质性

Identification of a basal stem cell subpopulation in the prostate via functional, lineage tracing and single-cell RNA-seq analyses

bioRxiv

NA

April, 2019

研究前列腺基底干细胞

Characterization of dendritic cell subtypes in human cord blood by single-cell sequencing

Biophysics Reports

NA

April, 2019

研究人脐带血中的树突状细胞的亚型

Cell BLAST: Searching large-scale scRNA-seq databases via unbiased cell embedding

bioRxiv

NA

April, 2019

单细胞数据分析方法

Single-cell transcriptome-based multilayer networkbiomarker for predicting prognosis and therapeuticresponse of gliomas

Briefings in Bioinformatics

6.302

April, 2019

开发单细胞数据分析方法

A 3D Atlas of Hematopoietic Stem and Progenitor Cell Expansion by Multi-dimensional RNA-Seq Analysis

Cell Report

7.815

May, 2019

斑马鱼造血干细胞

Dissecting the single-cell transcriptome network underlying gastric premalignant lesions and early gastric cancer

Cell Report

7.815

May, 2019

研究胃癌的早期病变

Genome assembly of a tropical maize inbred line provides insights into structural variation and crop improvement

Nature Genetics

25.455

May, 2019

组装玉米的基因组

Single-Cell Profiles and Clinically Useful Properties of Human Mesenchymal Stem Cells of Adipose and Bone Marrow Origin

The American Journal of Sports Medicine

6.057

May, 2019

研究脂肪组织和骨髓来源的间充质干细胞特征

Single-cell transcriptomic landscape of nucleated cells in umbilical cord blood

Gigascience

7.267

May, 2019

研究脐带血中有核细胞的异质性

VPAC: Variational projection for accurate clustering of single-cell transcriptomic data

BMC Bioinformatics

2.511

May, 2019

单细胞转录组数据分析方法的文章，提出了新的聚类方法

scRecover: Discriminating true and false zeros in single-cell RNA-seq data for imputation

bioRxiv

NA

June, 2019

单细胞转录组数据分析方法的文章，解决基因dropout问题

RobustClone: A robust PCA method of tumor clone and evolution inference from single-cell sequencing data

bioRxiv

NA

June, 2019

单细胞CNV数据分析方法，用于研究肿瘤进化

Proteomics and single-cell RNA analysis of Akap4-knockout mice model confirm indispensable role of Akap4 in spermatogenesis

Developmental Biology

2.936

June, 2019

研究*丸睾**中精子生成

The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cells

Cell Reports

7.815

June, 2019

研究果蝇肠内分泌细胞的异质性

A chromosome-scale genome assembly of cucumber (Cucumis sativus L.)

Gigascience

7.267

June, 2019

组装黄瓜基因组

The genome assembly and annotation of yellowhorn (Xanthoceras sorbifolium Bunge)

Gigascience

7.267

June, 2019

组装黄角花基因组

Vascularized human cortical organoids model cortical development in vivo

bioRxiv

NA

June, 2019

构建大脑皮层organoids模型

Inhibition of hyperglycolysis in mesothelial cells prevents peritoneal fibrosis

Science Translational Medicine

NA

June, 2019

研究腹膜纤维变性

Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma

Cell Research

17.848

July, 2019

研究胰腺导管癌

Comprehensive single-cell transcriptome lineages of a proto-vertebrate

Nature

41.577

July, 2019

海鞘胚胎发育单细胞转录谱

Single-Cell RNA-Seq of the Developing Cardiac Outflow Tract Reveals Convergent Development of the Vascular Smooth Muscle Cells

Cell Report

7.815

July, 2019

小鼠发育阶段心脏血管平滑肌细胞

An atlas of infiltrated B-lymphocytes in breast cancer revealed by paired single-cell RNA-sequencing and antigen receptor profiling

bioRxiv

NA

July, 2019

研究乳腺癌中浸润的B细胞

Single-cell transcriptome profiling reveals dermal and epithelium cell fate decisions during embryonic hair follicle development

bioRxiv

NA

July, 2019

研究胚胎期毛囊发育

Single-cell RNA sequencing profiling of the effects of aging on alveolar stem cells

Science China Life Sciences

3.583

July, 2019

研究肺泡干细胞

SET domain-containing protein 4 epigenetically controls breast cancer stem cell quiescence

Cancer Research

9.13

July, 2019

研究乳腺癌干细胞

Conversion of Astrocytes and Fibroblasts into Functional Noradrenergic Neurons

Cell Report

7.815

July, 2019

将星形胶质细胞和成纤维细胞转分化为神经细胞

The common neoantigens in colorectal cancer are predicted and validated to be presented or immunogenic

bioRxiv

NA

July, 2019

研究结直肠癌的抗原

Muscle-secreted G-CSF as a metabolic niche factor ameliorates loss of muscle stem cell in aged mice

bioRxiv

NA

July, 2019

研究肌肉干细胞

A draft genome for Spatholobus suberectus

Scientific Data

5.929

July, 2019

组装密花豆基因组

Optimal Gene Filtering for Single-Cell data (OGFSC)—a gene filtering algorithm for single-cell RNA-seq data

Bioinformatics

4.531

Aug, 2019

单细胞转录数据分析方法，用于降噪

Targeting Degradation of the Transcription Factor C/EBPβ Reduces Lung Fibrosis by Restoring Activity of the Ubiquitin-Editing Enzyme A20 in Macrophages

Immunity

21

Aug, 2019

研究巨噬细胞在肺纤维化中的作用

Single-Cell Transcriptomic Map of the Human and Mouse Bladders

Journal of the American Society of Nephrology

8.98

Aug, 2019

人和小鼠前列腺单细胞分析

B1 oligomerization regulates PML nuclear body biogenesis and leukemogenesis

Nature communications

11.88

Aug, 2019

癌蛋白的寡聚化调控白血病的发生

Single cell transcriptomic landscapes of pattern formation, proliferation and growth in Drosophila wing imaginal discs

Development

9.616

Aug, 2019

研究果蝇翅膀器官芽

Single-Cell RNA-Seq Reveals Naïve B cells Associated with Better Prognosis of HCC

bioRxiv

NA

Aug, 2019

研究肝癌中的免疫细胞

A high-quality genome assembly for the endangered golden snub-nosed monkey (Rhinopithecus roxellana)

Gigascience

7.267

Aug, 2019

组装金丝猴的基因组

Single-cell landscape in mammary epithelium reveals bipotent-like cells associated with breast cancer risk and outcome

Communications Biology

NA

Aug, 2019

单细胞数据分析发掘

Single-cell RNA-seq highlights heterogeneity in human primary Wharton’s Jelly mesenchymal stem/stromal cells cultured in vitro

bioRxiv

NA

Aug, 2019

研究间充质干细胞

Activation of Hedgehog Signaling Promotes Development of Mouse and Human Enteric Neural Crest Cells, Based on Single-Cell Transcriptome Analyses

Gastroenterology

20.877

Aug, 2019

研究Hedgehog信号通路如何调节胚胎干细胞向肠神经嵴分化

K-mer counting with low memory consumption enables fast clustering of single-cell sequencing data without read alignment

bioRxiv

NA

Aug, 2019

单细胞数据分析方法

Tracing the first hematopoietic stem cell generation in human embryo by single-cell RNA sequencing

Cell Research

17.848

Sep, 2019

研究人胚胎期造血干细胞

Single-cell transcriptomic landscape of cardiac neural crest cell derivatives during embryonic and neonatal development

bioRxiv

NA

Sep, 2019

研究胚胎及新生小鼠心神经嵴细胞的发育

SciBet: a fast classifier for cell type identification using single cell RNA sequencing data

Nature communications

11.88

Sep, 2019

单细胞转录组数据分析方法的文章，利用已有数据的细胞注释结果，对新的数据进行注释

Whole Genome Analyses of Chinese Population and De Novo Assembly of A Northern Han Genome

Genomics, Proteomics & Bioinformatics

6.597

Sep, 2019

组装汉族基因组

De novo assembly of a Tibetan genome and identification of novel structural variants associated with high altitude adaptation

bioRxiv

NA

Sep, 2019

组装藏族基因组

Chromosome‐level genome assembly of the razor clam Sinonovacula constricta (Lamarck, 1818)

Molecular Ecology Resources

7.059

Sep, 2019

组装剃刀贝基因组

Single-cell RNA-seq reveals RAD51AP1 as a potent mediator of EGFRvIII in human glioblastomas

Aging (Albany NY)

5.515

Sep, 2019

研究神经胶质瘤

Long-read assembly of the Chinese rhesus macaque genome and identification of ape-specific structural variants

Nature communications

11.88

Sep, 2019

组装猕猴基因组

Single-cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos

Immunity

21

Oct, 2019

构建了人类胚胎早期T淋巴细胞发育以及胸腺器官发生的分子图谱

Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development

bioRxiv

NA

Oct, 2019

研究人视网膜发育

Proteasome inhibitor induced SIRT1 deacetylates GLI2 to enhance hedgehog signaling activity and drug resistance in multiple myeloma

Oncogene

6.9

Oct, 2019

研究骨髓瘤的耐药性

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma

Cell

36.216

Oct, 2019

研究肝癌组织免疫微环境

Single-Cell Sequencing Reveals the Relationship between Phenotypes and Genotypes of Klinefelter Syndrome

Cytogenetic and Genome Research

1.587

Oct, 2019

研究克氏综合征

Enhancing single-cell cellular state inference by incorporating molecular network features

bioRxiv

NA

Oct, 2019

建立新的分析方法，研究细胞状态的改变

Zonation-dependent single-endothelial cell transcriptomic changes in the aged brain

bioRxiv

NA

Oct, 2019

研究脑组织衰老

Rapidly cycling stem cells regenerate the intestine independent of Lgr5high cells

bioRxiv

NA

Oct, 2019

研究小肠再生

CD24: a marker of granulosa cell subpopulation and a mediator of ovulation

Cell Death & Disease

5.959

Oct, 2019

研究卵巢颗粒细胞

Stress-Induced Metabolic Disorder in Peripheral CD4+ T Cells Leads to Anxiety-like Behavior

Cell

36.216

Oct, 2019

研究CD4+T细胞嘌呤合成代谢功能紊乱与心理疾病联系

Synchronized replication of genes encoding the same protein complex in fast-proliferating cells

Genome Research

9.944

Nov, 2019

研究细胞增殖

Mucosal Profiling of Pediatric-Onset Colitis and IBD Reveals Common Pathogenics and Therapeutic Pathways

Cell

36.216

Nov, 2019

研究小儿肠炎和炎症性肠病的发病机理及治疗方法

Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine

J Exp Med

10.892

Nov, 2019

研究人肠上皮细胞的异质性

Systematic comparative analysis of single-nucleotide variant detection methods from single-cell RNA sequencing data

Genome Biology

13.214

Nov, 2019

比较不同单细胞转录组测序方法在检测SNV方面的比较

HBsAg-specific CD8+ T cells as an indispensable trigger to induce murine hepatocellular carcinoma

Cellular & Molecular Immunology

8.213

Nov, 2019

研究HBV病毒诱导肝癌的机制

Chemical Cocktail Induces Hematopoietic Reprogramming and Expands Hematopoietic Stem/Progenitor Cells

Advanced Science

15.804

Nov, 2019

研究化合物诱导的重编程

The Cellular Diversity and Transcription Factor Code of Drosophila Enteroendocrine Cell

Cell Report

7.815

Dec, 2019

研究果蝇肠道中内分泌细胞的亚型、分布、转录因子代码及信号调控机制

Single cell atlas of domestic pig brain illuminates the conservation and divergence of cell types at spatial and species levels

bioRxiv

NA

Dec, 2019

构建家猪脑组织单细胞图谱

AutoGenome: An AutoML Tool for Genomic Research

bioRxiv

NA

Dec, 2019

开发数据分析方法

WEDGE: recovery of gene expression values for sparse single-cell RNA-seq datasets using matrix decomposition

bioRxiv

NA

Dec, 2019

开发数据分析方法

Mapping Human Pluripotent Stem Cell Derived Erythroid Differentiation by Single-Cell Transcriptome Analysis

bioRxiv

NA

Dec, 2019

研究红细胞发育

Single-Cell Map of Diverse Immune Phenotypes in the Metastatic Brain Tumor Microenvironment of Non Small Cell Lung Cancer

bioRxiv

NA

Dec, 2019

研究脑瘤微环境中的免疫细胞

SCSA: a cell type annotation tool for single-cell RNA-seq data

bioRxiv

NA

Dec, 2019

开发数据分析方法

Single-cell transcriptomics reveals diverse and complex gene expression alterations in human trisomy 18

bioRxiv

NA

Dec, 2019

分析18三体综合征

More than one antibody of individual B cells revealed by single-cell immune profiling

Cell Discovery

4.6

Dec, 2019

研究B细胞VDJ重排

A single-cell map for the transcriptomic signatures of peripheral blood mononuclear cells in end-stage renal disease

Nephrology Dialysis Transplantation

4.198

Dec, 2019

研究晚期肾病外周血单核细胞

A dominant autoinflammatory diseasecaused by non-cleavable variants of RIPK1

Nature

41.577

Dec, 2019

研究RIPK1蛋白所导致的自身免疫性炎症

Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells

Cell

36.216

Jan, 2020

研究特发性肺纤维化发病的机制

Arterial Sca1+ Vascular Stem Cells Generate De Novo Smooth Muscle for Artery Repair and Regeneration

Cell Stem Cell

21.464

Jan, 2020

研究血管干细胞

Single-cell RNA sequencing of human kidney

Scientific Data

5.929

Jan, 2020

构建人肾脏单细胞图谱

Single-cell RNA sequencing analysis reveals alginate oligosaccharides preventing chemotherapy-induced mucositis

Mucosal Immunology

7.352

Jan, 2020

研究化疗引起的粘膜炎

Single-cell RNA-seq reveals endoimmune cells in zebrafish

bioRxiv

NA

Jan, 2020

研究斑马鱼血管内皮细胞

Decoding the development of the human hippocampus

Nature

41.577

Jan, 2020

研究人脑海马区的早期发育

Single-cell transcriptome analyses recapitulate the cellular and developmental responses to abiotic stresses in rice

bioRxiv

NA

Jan, 2020

研究环境因素对水稻发芽的影响

Single cell atlas of trisomy 21 cerebral cortex

bioRxiv

NA

Jan, 2020

研究21三体综合症胎儿大脑皮层

scTPA: A web tool for single-cell transcriptome analysis of pathway activation signatures

bioRxiv

NA

Jan, 2020

开发了一个网页版单细胞数据分析工具，可以研究信号通路的激活

Isolation and long-term expansion of a single adult human renal epithelial cell with efficient kidney regeneration capacity

bioRxiv

NA

Jan, 2020

研究肾脏上皮细胞在体外的再生能力

Noninvasive Prenatal Diagnosis for Duchenne Muscular Dystrophy Based on the Direct Haplotype Phasing

Prenatal Diagnosis

2.4

Jan, 2020

用于无创DMD诊断

A single-cell transcriptome atlas during Cashmere goat hair follicle morphogenesis

bioRxiv

NA

Jan, 2020

研究山羊毛囊生成羊绒的机制

A high-quality chromosomal genome assembly of Diospyros oleifera Cheng

Gigascienc

7.267

Jan, 2020

组装油柿基因组

Liquid Biopsy-Based Single-Cell Transcriptome Profiling Characterizes Heterogeneity of DisseminatedTumor Cells from Lung Adenocarcinoma

Proteomics

3.106

Jan, 2020

研究肺癌病人胸积水

Discovery of peculiar cells in the peri-tumoral regions and peripheral blood of glioblastoma patients by single cell RNA-sequencing

bioRxiv

NA

Jan, 2020

研究神经胶质瘤

Identification of a Zeb1 expressing basal stem cell subpopulation in the prostate

Nature communications

11.88

Feb, 2020

研究前列腺基底干细胞

Imputing Single-cell RNA-seq data by combining Graph Convolution and Autoencoder Neural Networks

bioRxiv

NA

Feb, 2020

研究单细胞数据分析方法

Global Dynamic Molecular Profiles of Stomatal Lineage Cell Development by Single-Cell RNA Sequencing

bioRxiv

NA

Feb, 2020

研究拟南芥幼芽

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

Cell

36.216

Feb, 2020

研究细胞节食对大鼠各器官的影响

The landscape of lung bronchoalveolar immune cells in COVID-19 revealed by single-cell RNA sequencing

bioRxiv

NA

Feb, 2020

第一篇用COVID-19病人样本做的文章，研究病毒引起的免疫反应

Single-Cell RNA Sequencing Reveals Size-Dependent Effects of Polystyrene Microplastics on Immune and Secretory Cell Populations from Zebrafish Intestines

Environmental Science & Technology

7.14

Feb, 2020

研究斑马鱼肠组织

scTSSR: gene expression recovery for single-cell RNA sequencing using two-side sparse self-representation

Bioinformatics

4.531

Feb, 2020

开发单细胞数据分析方法

Profiling ACE2 expression in colon tissue of healthy adults and colorectal cancer patients by single-cell transcriptome analysis

bioRxiv

NA

Feb, 2020

分析正常人结肠样本和结肠癌样本

Integrated decoding hematopoiesis and leukemogenesis at single-cell resolution and its clinical implication

bioRxiv

NA

Feb, 2020

研究造血和白血病发生

Spatiotemporal single-cell analysis of geneexpression in the mouse suprachiasmatic nucleus

Nature Neuroscience

21.126

Feb, 2020

研究小鼠视交叉上核

Characteristics, dynamic changes, and prognostic significance of TCR repertoire profiling in renal cell carcinoma patients

The Journal of Pathology

6.253

Feb, 2020

研究肾癌样本中TCR库

Single-cell ATAC-seq clustering and differential 2 analysis by convolution-based approach

bioRxiv

NA

Feb, 2020

开发单细胞ATAC数据分析方法

Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal cancer

Cancer Letters

6.491

Feb, 2020

研究鼻咽癌组织中浸润的免疫细胞

Dissecting Esophageal Squamous-Cell Carcinoma Ecosystem by Single-Cell Transcriptomic Analysis

Cancer Cell

22.844

Feb, 2020

研究食管鳞状细胞组织中浸润的免疫细胞

Single-cell RNA sequencing of immune cells in gastric cancer patient

Aging

5.515

Feb, 2020

研究胃癌样本中的免疫细胞

Two waves of pro-inflammatory factors are released during the influenza A virus (IAV)-driven pulmonary immunopathogenesis

PLOS Pathogens

6.1

Feb, 2020

研究流感感染后的免疫反应

The Integrated Transcriptome Bioinformatics Analysis Identifies Key Genes and Cellular Components for Spinal Cord Injury-Related Neuropathic Pain

Front. Bioeng. Biotechnol

4.2

Feb, 2020

研究脊髓损伤相关的神经性疼痛的关键基因和细胞成分

Alginate oligosaccharides improve germ cell development and testicular microenvironment to rescue busulfan disrupted spermatogenesis

Theranostics

8.7

Feb, 2020

研究生殖细胞和*丸睾**微环境

Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma

Cancer Letters

6.491

Feb, 2020

研究鼻咽癌中的免疫细胞

Genetic characterization of stem cell-like cancer cell in the peri-tumoral regions and proliferative lymphocyte in the peripheral blood of patients with glioblastoma

bioRxiv

NA

Feb, 2020

研究神经胶质瘤患者肿瘤周围区域干细胞样癌细胞和外周血增殖淋巴细胞的遗传特征

Single-cell RNA sequencing of immune cells in gastric cancer patients

Aging

5.515

Feb, 2020

研究胃癌患者的免疫细胞

High expression of ACE2 receptor of 2019-nCoV on the epithelial cells of oral mucosa

International journal of oral science

2.79

Feb, 2020

口腔黏膜上皮细胞中ACE2受体的表达

Long-Term Expansion of Pancreatic Islet Organoids from Resident Procr+ Progenitors

Cell

36.216

Mar, 2020

研究胰岛类器官长期体外培养

Identifcation of a potential mechanism of acute kidney injury during the COVID-19 outbreak: a study based on single-cell transcriptome analysis

Intensive Care Medicine

18.9

Mar, 2020

研究COVID-19病人急性肾损伤的原因

DAISM-DNN: Highly accurate cell type proportion estimation with in silico data augmentation and deep neural networks

bioRxiv

NA

Mar, 2020

单细胞分析方法

Single-cell transcriptome profiling an adult human cell atlas of 15 major organs

bioRxiv

NA

Mar, 2020

人的细胞图谱，做了15组织

Single cell chromatin accessibility of the developmental cephalochordate

bioRxiv

NA

Mar, 2020

研究脊索动物的发育

Dimension Reduction and Clustering Models for Single-Cell RNA Sequencing Data: A Comparative Study

International Journal of Molecular Sciences

4.3

Mar, 2020

开发单细胞转录组数据分析方法

SCYN: Single cell CNV profiling method using dynamic programming

bioRxiv

NA

Mar, 2020

开发单细胞CNV算法

Single-cell transcriptomics of blood reveals a natural killer cell subset depletion in tuberculosis

EBioMedicine

6.6

Mar, 2020

研究结核病的NK细胞

Recapitulation of SARS-CoV-2 Infection and Cholangiocyte Damage with Human Liver Organoids

bioRxiv

NA

Mar, 2020

用人类肝类器官模拟SARS-CoV-2感染导致的胆管细胞损伤

Blood single cell immune profiling reveals the interferon-MAPK pathway mediated adaptive immune response for COVID-19

bioRxiv

NA

Mar, 2020

COVID-19病人免疫系统

Significant Evolutionary Constraints on Neuron CellsRevealed by Single-Cell Transcriptomics

Genome Biology and Evolution

3.462

Mar, 2020

数据分析方法

Single-cell RNA-seq data analysis on the receptor ACE2expression reveals the potential risk of different human organs vulnerable to 2019-nCoV infection

Frontiers of Medicine

1.8

Mar, 2020

研究新冠病毒感染各器官的风险

Complement Signals Determine Opposite Effectsof B Cells in Chemotherapy-Induced Immunity

Cell

36.216

Mar, 2020

研究B细胞在化疗治疗后的响应

Characteristics, dynamic changes, and prognostic significance of TCRrepertoire profiling in patients with renal cell carcinoma

Journal of Pathology

5.78

Mar, 2020

研究肾细胞癌患者TCR表达谱的特征，动态变化和预后意义

Single-cell RNA sequencing deconvolutes the in vivo heterogeneity of human bone marrow-derived mesenchymal stem cells

bioRxiv

NA

April, 2020

研究骨髓来源的间充质干细胞

Heterogeneity of exhausted T cells in the tumor microenvironment is linked to patient survival following resection in hepatocellular carcinoma

Oncoimmunology

5.3

April, 2020

研究肝癌病人中耗竭T细胞的异质性

Single-cell RNA-seq highlightsheterogeneity in human primary Wharton’sjelly mesenchymal stem/stromal cellscultured in vitro

Stem cell research & therapy

3

April, 2020

研究脐带胶质来源的间充质干细胞的异质性

Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer

Cell

36.216

April, 2020

结肠癌细胞治疗

Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia

Aging and Disease

4.1

April, 2020

间充质干细胞治疗COVID-19

Single cell transcriptomics of human nephritis reveal the cellular origin of kidney disease associated genes

bioRxiv

NA

April, 2020

研究肾炎的致病机理

Revealing Cellular Heterogeneity and In Vitro Differentiation Trajectory of Cultured Human Endometrial Mesenchymal-like Stem Cells Using Single-cell RNA Sequencing

bioRxiv

NA

April, 2020

研究人子宫内膜间充质样干细胞的异质性和体外分化轨迹

Association Analysis of Single-Cell RNA Sequencingand Proteomics Reveals a Vital Role of Ca2+ Signalingin the Determination of Skeletal Muscle Development Potential

Cells

5.656

April, 2020

研究骨骼肌发育

Single-cell transcriptome profiling reveals vascular endothelial cell heterogeneity in human skin

Theranostics

11.556

April, 2020

皮肤血管内皮细胞的组织特征及亚群异质性

Immune Cell Profiling of COVID-19 Patients in the recovery stage by Single-cell sequencing

Cell Discovery

4.6

May, 2020

研究COVID-19恢复期病人免疫系统

Genome and single-cell RNA-sequencing of the earthworm Eisenia andrei identifies cellular mechanisms underlying regeneration

Nature communications

11.88

May, 2020

研究蚯蚓的再生机制

Single-cell RNA-seq and V(D)J profiling of immune cells in COVID-19 patients

bioRxiv

NA

May, 2020

研究COVID-19病人免疫系统

Single cell chromatin accessibility of the developmental cephalochordate

bioRxiv

NA

May, 2020

研究女性生殖细胞发育

Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer

Cell Research

17.848

May, 2020

研究大肠癌中浸润的免疫细胞

Single cell RNA sequencing reveals regulation of fetal ovary development in the monkey (Macaca fascicularis)

bioRxiv

NA

May, 2020

研究猴子胎儿卵巢发育的调控

Potent Neutralizing Antibodies against SARS-CoV-2Identified by High-Throughput Single-CellSequencing of Convalescent Patients’ B Cells

Cell

36.216

May, 2020

研究新冠病人体内广泛中和抗体

SCSA: A Cell Type Annotation Tool for Single-Cell RNA-seq Data

Frontiers in Genetics

3.36

May, 2020

开发单细胞注释方法

Single cell RNA sequencing of 13 human tissues identify cell types andreceptors of human coronaviruses

Biochemical and Biophysical Research Communications

2.985

May, 2020

分析不同组织中新冠病毒受体的表达

Trajectory and Functional Analysis of PD‐1high CD4+CD8+ T Cells in Hepatocellular Carcinoma by Single‐Cell Cytometry and Transcriptome Sequencing

Advanced Science

15.804

May, 2020

研究肝癌组织中的T细胞

A single-cell transcriptomic landscape of primate arterial aging.pdf

Nature communications

11.88

May, 2020

研究动脉衰老

Aortic heterogeneity across segments and under high fat/salt/glucose conditions at the single-cell level

National Science Review

16.6

May, 2020

研究小鼠主动脉异质性

The Msi1-mTOR pathway drives the pathogenesis of mammary and extramammary Paget’s disease

Cell Research

17.848

May, 2020

研究派杰氏病的患病机制

Increased Connexin36 Phosphorylation in AII Amacrine Cell Coupling of the Mouse Myopic Retina

Frontiers in Cellular Neuroscience

3.9

June, 2020

研究近视眼视网膜病变的机制

Adverse effects of nicotine on cardiogenic differentiation from human embryonic stem cells detected by single-cell RNA sequencing

Biochemical and Biophysical Research Communications

2.985

June, 2020

研究尼古丁对人心脏分化的影响

Single-cell Transcriptome Profiling reveals Dermal andEpithelial cell fate decisions during Embryonic HairFollicle Development

Theranostics

8.7

June, 2020

研究胚胎期毛囊发育

Single-cell transcriptome and antigenimmunoglobin analysis reveals the diversity of B cells in non-small cell lung cancer

Genome Biology

10.8

June, 2020

研究非小细胞肺癌中的B细胞

Single-cell transcriptional atlas of the Chinese horseshoe bat (Rhinolophus sinicus) provides insight into the cellular mechanisms which enable bats to be viral reservoirs

bioRxiv

NA

June, 2020

研究马蹄蝙蝠的单细胞图谱

Deciphering the Landscape of Peripheral Blood T Cells via Single-Cell RNA-Seq in Chronic Lymphocytic Leukemia

bioRxiv

NA

June, 2020

研究慢性淋巴细胞性白血病中的T细胞。

An entropy-based metric for assessing the purity of single cell populations

Nature communications

11.88

June, 2020

开发数据分析方法

Dissecting transcriptional heterogeneity in primary gastric adenocarcinoma by single cell RNA sequencing

Gut

19.8

June, 2020

构建胃癌单细胞图谱

Putative regulators for the continuum of erythroid differentiation revealed by single-cell transcriptome of human BM and UCB cells

PNAS

9.58

June, 2020

研究类红细胞分化的关键调控因子

Clustering and classification methods for single-cell RNA-sequencing data

Briefings in Bioinformatics

8.99

July, 2020

开发单细胞聚类方法

Normalizing single-cell RNA sequencing data with internal spike-in-like genes

bioRxiv

NA

July, 2020

开发单细胞数据均一化方法

Single-cell analysis reveals bronchoalveolar epithelial dysfunction in COVID-19 patients

Protein&Cell

7.575

July, 2020

研究COVID-19病人支气管肺泡上皮细胞

Single-cell landscape of immunological responses in COVID-19 patients

bioRxiv

NA

July, 2020

研究COVID-19病人免疫系统

HIT-scISOseq: High-throughput and High-accuracy Single-cellFull-length Isoform Sequencing for Corneal Epithelium

bioRxiv

NA

July, 2020

研究角膜mRNA全长可变剪切

Single-cell sequencing reveals heterogeneity effects of bisphenol A on zebrafish embryonic development

Environmental Science & Technology

7.149

July, 2020

研究双酚A对斑马鱼胚胎发育的影响

High-dimensional single-cell analysis delineatesradiofrequency ablation induced immunemicroenvironmental remodeling in pancreaticcancer

Cell Death and Disease

5.91

July, 2020

研究射频消融诱导的胰腺癌免疫微环境重塑

The molecular taxonomy of primate amygdala via single-nucleus RNA-sequencing analysis

bioRxiv

NA

July, 2020

研究灵长类杏仁核

Single-cell analysis reveals the function of lung progenitor cells in COVID-19 patients

bioRxiv

NA

July, 2020

研究COVID-19病人肺的多能功能干细胞

Single‐cell RNA sequencing reveals the landscape of early female germ cell development

FASEB Journal

5

July, 2020

研究女性早期生殖细胞发育

Unveiling transposable element expression heterogeneity in cell fate regulation at the single-cell level

bioRxiv

NA

July, 2020

研究细胞命运决定

Comparative analysis of cell lineage differentiation duringhepatogenesis in humans and mice at the single-celltranscriptome level

Cell Research

17.848

July, 2020

研究小鼠和人的肝脏发育

A single-cell transcriptome atlas of the aging human and macaque retina

bioRxiv

NA

July, 2020

人类和猕猴视网膜的单细胞转录组图谱

Searching large-scale scRNA-seq databases via unbiased cell embedding with Cell BLAST

Nature communications

11.88

July, 2020

开发单细胞数据分析方法

Single-cell transcriptomics reveals regulators underlyingimmune cell diversity and immune subtypes associated with prognosis in nasopharyngeal carcinoma

Cell Research

17.848

July, 2020

研究鼻咽癌中免疫细胞多样性

Single-cell profiling reveals sex diversity in human renal proximal tubules

Gene

3.331

Aug, 2020

研究人肾近端小管中的性别多样性

Adaptive immune responses to SARS-CoV-2 infection in severe versus mild individuals

Signal Transduction and Targeted Therapy

NA

Aug, 2020

重症和轻度个体对SARS-CoV-2感染的适应性免疫反应

Dysregulated adaptive immune response contributes to severe COVID-19

Cell Research

17.848

Aug, 2020

适应性免疫失调在COVID-19重症发生中的重要作用

A human circulating immune cell landscapein aging and COVID-19

Protein&Cell

7.575

Aug, 2020

老年COVID-19病人的免疫图谱

Single-cell analysis of two severe COVID-19 patients reveals a monocyte-associated and tocilizumab-responding cytokine storm

Nature communications

11.88

Aug, 2020

研究托珠单抗治疗后的COVID-19病人样本

Single-cell transcriptomics identifies a distinct luminal progenitor cell type in distal prostate invagination tips

Nature Genetics

25.455

Aug, 2020

研究前例腺多能干细胞

Single-cell RNA-Seq reveals the transcriptional landscape and heterogeneity of skin macrophages in Vsir-/- murine psoriasis

Theranostics

8.7

Aug, 2020

研究银屑病病*皮人**肤中的巨噬细胞

Dynamic cell transition and immune response landscapes of axolotl limb regeneration revealed by single-cell analysis

Protein&Cell

7.575

Aug, 2020

研究蝾螈肢体再生

Single-cell RNA-seq reveals the immune escape and drugresistance mechanisms of mantle cell lymphoma

Cancer Biology & Medicine

5.4

Aug, 2020

研究淋巴瘤的耐药机制

Single-cell landscape of immunological responses in patients with COVID-19

Nature immunology

20.47

Sep, 2020

COVID-19患者的免疫反应的单细胞图谱

Pharmacologically reversible zonation-dependentendothelial cell transcriptomic changes withneurodegenerative disease associations in the agedbrain

Nature communications

11.88

Sep, 2020

研究神经退行性疾病

Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma

Cell Research

17.848

Sep, 2020

揭示鼻咽癌肿瘤细胞的双重特性

Single-nucleus RNA-seq resolves spatiotemporal developmental trajectories in the tomato shoot apex

bioRxiv

NA

Sep, 2020

单细胞核测序研究番茄顶芽

Dimensionality reduction for single cell RNA sequencing data using constrained robust non-negative matrix factorization

NAR Genomics and Bioinformatics

NA

Sep, 2020

开发数据分析方法

Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma

Signal Transduction and Targeted Therapy

5.8

Sep, 2020

研究骨肉瘤的治疗方法

Single-nucleus transcriptome analysis reveals dysregulation of angiogenic endothelial cells and neuroprotective glia in Alzheimer’s disease

PNAS

9.58

Sep, 2020

研究阿尔斯海默症

Single-cell transcriptomic atlas of primate cardiopulmonary aging

Cell Research

17.848

Sep, 2020

研究灵长类心肺的衰老 （单细胞核测序）

Cell Development Deficiency and Gene Expression Dysregulation of Trisomy 21 Retina Revealed by Single-Nucleus RNA Sequencing

Frontiers in Bioengineering and Biotechnology

4.2

Sep, 2020

研究21三体综合症患者视网膜

Single-cell immune landscape of human recurrent spontaneous abortion

Cell Report

7.815

Sep, 2020

构建反复自然流产的单细胞免疫图谱

Identification of a novel cancer stem cell subpopulation that promotes progression of human fatal renal cell carcinoma by single-cell RNA-seq analysis

International Journal of Biological Sciences

3.8

Oct, 2020

研究人幼儿肾癌中的干细胞

Single‐Cell Transcriptomics of Engineered Cardiac Tissues From Patient‐Specific Induced Pluripotent Stem Cell–Derived Cardiomyocytes Reveals Abnormal Developmental Trajectory and Intrinsic Contractile Defects in Hypoplastic Right Heart Syndrome

Journal of the American Heart Association

2.382

Oct, 2020

研究iPS诱导分化的心肌细胞

Reclassification of classic T cell subsets and identification of novel cell types by single-cell RNA sequencing

bioRxiv

NA

Oct, 2020

研究外周血T细胞的亚型

A Unique Population of Regulatory T Cells in Heart Potentiates Cardiac Protection from Myocardial Infarction

Circulation

23.6

Oct, 2020

研究调节性T细胞在心机梗塞中的作用

Cell populations in neonatal rat peripheral nerves identified by single‐cell transcriptomics

Glia

6.2

Oct, 2020

研究幼年大鼠外周神经组织的细胞异质性

Single-cell RNA-seq data semi-supervised clustering and annotation via structural regularized domain adaptation

Bioinformatics

4.531

Oct, 2020

开发单细胞数据分析方法

Single-Cell RNA-Sequencing Shift in the Interaction Pattern Between Glioma Stem Cells and Immune Cells During Tumorigenesis

Frontiers in Immunology

5

Oct, 2020

研究神经胶质瘤

Single-Cell RNA-Seq Reveals that CD9 Is a Negative Marker of Glucose-Responsive Pancreatic β-like Cells Derived from Human Pluripotent Stem Cells

Stem Cell Reports

6

Oct, 2020

研究CD9阳性的胰岛β样细胞

Cell-Type Transcriptome Atlas of Human Aortic Valves Reveal Cell Heterogeneity and Endothelial to Mesenchymal Transition Involved in Calcific Aortic Valve Disease

Arteriosclerosis, Thrombosis, and Vascular Biology

6.6

Oct, 2020

研究主动脉瓣细胞异质性

scAIDE: clustering of large-scale single-cell RNA-seq data reveals putative and rare cell types

NAR Genomics and Bioinformatics

NA

Oct, 2020

开发单细胞数据分析方法

Single-cell RNA sequencing highlights the role of inflammatory cancer-associated fibroblasts in bladder urothelial carcinoma

Nature communications

11.88

Oct, 2020

研究膀胱尿路上皮癌中的炎症相关成纤维细胞

Single-cell RNA-seq reveals different subsets of non-specific cytotoxic cells in teleost

Genomics

6.2

Nov, 2020

研究硬骨鱼中的细胞毒性细胞

An interpretable deep-learning architecture of capsule networks for identifying cell-type gene expression programs from single-cell RNA-sequencing data

Nature Machine Intelligence

16

Nov, 2020

开发单细胞数据分析方法

Single-cell RNA sequencing reveals heterogeneous tumor and immune cell populations in early-stage lung adenocarcinomas harboring EGFR mutations

Oncogene

6.9

Nov, 2020

研究EGFR突变肺癌病人的肿瘤细胞及免疫细胞的异质性

scAPAtrap: identification and quantification of alternative polyadenylation sites from single-cell RNA-seq data

Briefings in Bioinformatics

6.302

Nov, 2020

开发单细胞数据分析方法

Single-cell transcriptome profiling reveals the mechanism of abnormal proliferation of epithelial cells in congenital cystic adenomatoid malformation

Experimental Cell Research

3.2

Nov, 2020

研究先天性囊性腺瘤样畸形

Single-Cell Characterization of Malignant Phenotypes and Developmental Trajectories of Adrenal Neuroblastoma

Cancer Cell

22.844

Nov, 2020

研究肾上腺神经母细胞瘤

Single cell transcriptomic architecture and intercellular crosstalk of human intrahepatic cholangiocarcinoma

Journal of Hepatology

18.946

Nov, 2020

研究胆管癌

Single-cell analysis of developing and azoospermia human testicles reveals central role of Sertoli cells

Nature communications

11.88

Nov, 2020

研究精子发育

Liver immuneprofiling reveals pathogenesis and therapeutics for biliary atresia

Cell

36.216

Nov, 2020

新生儿胆道闭锁的发病机制和新的治疗策略

Single cell RNA and immune repertoire profiling of COVID-19 patients reveal novel neutralizing antibody

Protein&Cell

7.575

Nov, 2020

筛选高效的新冠病毒中和抗体

Decoding human megakaryocyte development

Cell Stem Cell

21.464

Dec, 2020

研究人类巨核细胞发育

Single-cell landscape of the ecosystem in earlyrelapse hepatocellular carcinoma

Cell

36.216

Jan, 2021

研究早期复发性肝细胞癌全景图谱

Sequential fate-switches in stem-like cells drive the tumorigenic trajectory from human neural stem cells to malignant glioma

Cell Research

17.848

Jan, 2021

研究恶性神经胶质瘤的发病机理

Single-cell analysis reveals transcriptomic remodellings in distinct cell types that contribute to human prostate cancer progression

Nature Cell Biology

20.042

Jan, 2021

研究前列腺发展过程中的细胞重塑

Single cell ATAC-Seq reveals cell type-specific transcriptional regulation and unique chromatin accessibility in human spermatogenesis

Human Molecular Genetics

5.1

Jan, 2021

研究人类精子发生

Decoding the multicellular ecosystem of lung adenocarcinoma manifested as pulmonary subsolid nodules by single-cell RNA sequencing

Science Advances

13

Jan, 2021

研究肺腺癌肿瘤微环境特征

Identification of Novel Population-Specific Cell Subsets in Chinese Ulcerative Colitis Patients Using Single-Cell RNA Sequencing

Cellular and Molecular Gastroenterology and Hepatology

7

Jan, 2021

使用单细胞 RNA 测序鉴定中国溃疡性结肠炎患者的新型种群特异性细胞亚群

Single-cell Immune Landscape of Human Recurrent Miscarriage

Genomics, Proteomics & Bioinformatics

6.41

Jan, 2021

人类复发性流产的单细胞免疫图谱

Single-cell transcriptome profiling of the vaginal wall in women with severe anterior vaginal prolapse

Nature communications

11.88

Jan, 2021

严重前阴道脱垂女性阴道壁的单细胞转录组分析

Dissecting human embryonic skeletal stem cell ontogeny by single-cell transcriptomic and functional analyses

Cell Research

17.848

Jan, 2021

通过单细胞转录组学和功能分析剖析人胚胎骨骼干细胞个体发育

Tumour Heterogeneity and Intercellular Networks of Nasopharyngeal Carcinoma at Single Cell Resolution

Nature communications

11.88

Feb, 2021

研究鼻咽癌肿瘤微环境的细胞异质性及其动态变化

A pan-cancer single-cell transcriptional atlas of tumor infiltrating myeloid cells

Cell

36.216

Feb, 2021

泛癌种尺度下肿瘤浸润髓系细胞的单细胞转录图谱

FlsnRNA-seq: protoplasting-free full-length single-nucleus RNA profiling in plants

Genome Biology

13.214

Feb, 2021

开发植物中的单核水平上的、大规模的全长RNA分析技术

Epigenetic landscapes of single-cell chromatin accessibility and transcriptomic immune profiles of T cells in COVID-19 patients

Frontiers in Immunology

5.1

Feb, 2021

研究新冠样本染色质可及性和T细胞转录组免疫图谱

Single-cell transcriptomes of peripheral blood cells indicate and elucidate severity of COVID-19

Science China Life Sciences

4.6

Feb, 2021

外周血细胞的单细胞转录组指示并阐明了COVID-19的严重程度

Single-cell RNA sequencing reveals species-specific time spans of cell cycle transitions in early oogenesis

Human Molecular Genetics

4.611

Feb, 2021

单细胞RNA测序揭示了早期卵子发生

Single-Cell Transcriptome Profiling RevealsIntratumoral Heterogeneity in Human Chordomas

bioRxiv

NA

Feb, 2021

单细胞转录组分析揭示人类脊索瘤的瘤内异质性

iMAP: integration of multiple single-cell datasets by adversarial paired transfer networks

Genome Biology

13.214

Feb, 2021

数据整合工具

Single-cell RNA-Seq revealed profound immune alteration in the peripheral blood of patients with bacterial infection

International Journal of Infectious Diseases

3.538

Feb, 2021

细菌感染患者外周血单细胞图谱

Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome

Frontiers in Immunology

6.429

Feb, 2021

原发性干燥综合征中细胞毒性 CD4+ T 淋巴细胞的扩增和免疫细胞的分布

A Single-Cell Transcriptomic Atlas of Human Skin Aging

Developmental Cell

10.092

Feb, 2021

人类皮肤衰老的单细胞转录组学图谱

Transcriptional landscape of rice roots at the single-cell resolution

Molecular Plant

9.326

Mar, 2021

水稻根单细胞测序

MAP3K2-regulated intestinal stromal cells define a distinct stem cell niche

Nature

41.577

Mar, 2021

发现新型肠道间质细胞并揭示其在炎症过程中调控肠道干细胞损伤修复机制

Identifying transposable element expression dynamics and heterogeneity during development at the single-cell level with a processing pipeline scTE

Nature communications

11.88

Mar, 2021

开发单细胞测序分析转座元件表达的工具scTE

Sequential progenitor states mark the generation of pancreatic endocrine lineages in mice and humans

Cell Research

17.848

Mar, 2021

研究胰腺内分泌细胞发育

Single-cell transcriptomic analysis of somatosensory neurons uncovers temporal development of neuropathic pain

Cell Research

17.848

Mar, 2021

研究神经性疼痛的机制

A single-cell analysis of the Arabidopsis vegetative shoot apex

Developmental Cell

10.092

Mar, 2021

在单细胞水平揭示了拟南芥茎尖细胞的异质性

Liver type 1 innate lymphoid cells develop locally via an interferon-γ-dependent loop

Science

37.205

Mar, 2021

发现天然淋巴细胞的骨髓外发育新路径

Single-cell RNA sequencing reveals the cellular origin and evolutionof breast cancer in BRCA1 mutation carriers

Cancer Research

9.13

Mar, 2021

揭示乳腺癌的细胞起源和进化

A single-cell survey of the human glomerulonephritis

Journal of Cellular and Molecular Medicine

4.658

Mar, 2021

研究人类肾小球肾炎

Single-cell transcriptomics uncovers phenotypic alterations in the monocytes in a Chinese population with chronic cadmium exposure

Ecotoxicology and Environmental Safety

6.291

Mar, 2021

单细胞转录组学揭示慢性镉暴露中国人群单核细胞的表型改变

Single-Cell Transcriptome Analysis Uncovers Intratumoral Heterogeneity and Underlying Mechanisms for Drug Resistance in Hepatobiliary Tumor Organoids

Advanced Science

16.806

Mar, 2021

单细胞转录组分析揭示了肝胆肿瘤类器官的肿瘤内异质性和耐药机制

Single-Cell Transcriptome Atlas and Chromatin Accessibility Landscape Reveal Differentiation Trajectories in the Rice Root

Nature communications

11.88

Apr, 2021

水稻根单细胞异质性和分化全景图

COVID-19 immune features revealed by a large-scale single-cell transcriptome atlas

Cell

36.216

Apr, 2021

研究COVID-19病人免疫系统

Identification of Silkworm Hemocyte Subsets and Analysis of Their Response to Baculovirus Infection Based on Single-Cell RNA Sequencing

Frontiers in Immunology

5.1

Apr, 2021

家蚕血细胞亚群的鉴定及其对杆状病毒感染的反应分析

A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish

PNAS

9.4

Apr, 2021

单细胞水平揭示了斑马鱼造血干细胞扩增的动态图谱

Atlas of breast cancer infiltrated B-lymphocytes revealed by paired single-cell RNA-sequencing and antigen receptor profiling

Nature communications

11.88

Apr, 2021

揭示的乳腺癌浸润 B 淋巴细胞图谱

Identifying the functions of two biomarkers in human oligodendrocyte progenitor cell development

Journal ofTranslational Medicine

4.2

May, 2021

研究少突胶质祖细胞发育

Molecular identity of human limbal heterogeneity involved in corneal homeostasis and privilege

Ocular Surface

12.336

May, 2021

研究人角膜干细胞及微环境

Coupled analysis of transcriptome and BCR mutations reveals role of OXPHOS in affinity maturation

Nature immunology

20.47

May, 2021

揭示了氧化磷酸化通路在生发中心B细胞亲和力正向筛选中的关键作用。

Mouse totipotent stem cells captured and maintained through spliceosomal repression

Cell

36.216

May, 2021

小鼠ESCs剪接体抑制驱动多能到全能状态转换

Single-cell transcriptomes reveal characteristic features of cell types within the human adrenal microenvironment

Journal of Cellular Physiology

5.546

May, 2021

单细胞转录组揭示人类肾上腺微环境中细胞类型的特征

Global characterization of B cell receptor repertoire in COVID-19 patients by single-cell V(D)J sequencing

Briefings in Bioinformatics

11.622

May, 2021

COVID-19 患者B细胞受体库

Single-cell RNA sequencing reveals the sustained immune cell dysfunction in the pathogenesis of sepsis secondary to bacterial pneumonia

Genomics

5.736

May, 2021

揭示细菌性肺炎继发脓毒症发病机制中持续的免疫细胞功能障碍

Single-cell transcriptome atlas of the leaf and root of rice seedlings

Journal of Genetics and Genomics

4.65

Jun, 2021

绘制单子叶模式植物水稻的单细胞转录图谱

The chromosome-level reference genome of Coptis chinensis provides insights into genomic evolution and berberine biosynthesis

Horticulture Research

5.676

Jun, 2021

构建黄连的参考基因组

Single-cell RNA-seq describes the transcriptome landscape and identifies critical transcription factors in the leaf blade of the allotetraploid peanut (Arachis hypogaea L.)

Plant Biotechnology Journal

9.803

Jun, 2021

花生叶片组织单细胞图谱

Hypoxic microenvironment induced spatial transcriptome changes in pancreatic cancer

Cancer Biology & Medicine

4.248

Jun, 2021

缺氧微环境诱导胰腺癌组织内空间转录组的变化

Smek1 deficiency exacerbates experimental autoimmune encephalomyelitis by activating proinflammatory microglia and suppressing the IDO1-AhR pathway

Journal of Neuroinflammation

8.322

Jun, 2021

Smek1缺乏通过激活促炎性小胶质细胞和抑制IDO1-AhR途径加重实验性自身免疫性脑脊髓炎

Single-cell analyses reveal suppressive tumor microenvironment of human colorectal cancer

Clinical and Translational Medicine

11.492

Jun, 2021

单细胞分析揭示了人类结直肠癌的抑制性肿瘤微环境

Single-Cell RNA-seq Identification of the Cellular Molecular Characteristics of Sporadic Bilateral Clear Cell Renal Cell Carcinoma

Frontiers in Oncology

6.244

Jun, 2021

散发性双侧透明细胞肾细胞癌细胞单细胞图谱

Single-Cell Transcriptomic Analysis Reveals a Hepatic Stellate Cell–Activation Roadmap and Myofibroblast Origin During Liver Fibrosis in Mice

Hepatology

17.425

Jun, 2021

小鼠肝纤维化过程中的肝星状细胞激活路线图和肌成纤维细胞起源

Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment

Nature communications

11.88

Jun, 2021

单细胞转录组学分析揭示了人类 Treg

Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells

Cell Research

17.848

Jul, 2021

解析人类固有淋巴细胞起源

The zinc finger protein Miz1 suppresses liver tumorigenesis by restricting hepatocyte-driven macrophage activation and inflammation

Immunity

31.745

Jul, 2021

锌指蛋白Miz1通过限制肝细胞驱动的巨噬细胞活化和炎症来抑制肝脏肿瘤发生

Single-cell atlas of domestic pig cerebral cortex and hypothalamus

Science Bulletin

11.78

Jul, 2021

家猪大脑皮层和下丘脑的单细胞图谱

Single-cell spatial transcriptomic analysis reveals common and divergent features of developing postnatal granule cerebellar cells and medulloblastoma

BMC Biology

5.914

Jul, 2021

单细胞空间转录组学分析揭示了出生后颗粒小脑细胞和成神经管细胞瘤的共同和不同特征

Identification of HSC/MPP expansion units in fetal liver by single-cell spatiotemporal transcriptomics

Cell Research

17.848

Aug, 2021

研究胎儿肝脏中的造血干细胞和多能干细胞

Multiomic analyses reveal a critical role of selenium in controlling T cell differentiation in Crohn’s disease

Immunity

31.745

Aug, 2021

肝细胞癌肿瘤微环境

Single-cell transcriptomic landscape reveals tumor specific innate lymphoid cells associated with colorectal cancer progression

Cell Report

7.815

Aug, 2021

结直肠癌天然淋巴细胞图

Insulin signaling establishes a developmental trajectory of adipose regulatory T cells

Nature immunology

20.47

Aug, 2021

揭示脂肪组织Treg不同亚型分化及其功能调控新机制

Spatiotemporal Immune Landscape of Colorectal Cancer Liver Metastasis at Single-Cell Level

Cancer Discovery

39.4

Aug, 2021

结直肠癌肝转移的免疫动态变化

A versatile and scalable single-cell data integration algorithm based on domain-adversarial and variational approximation

Briefings in Bioinformatics

11.622

Sep, 2021

开发数据分析工具

Transcriptomic Landscape of Circulating Mononuclear Phagocytes in Langerhans Cell Histiocytosis at Single-cell Level

Blood

17.794

Oct, 2021

解析LCH单核吞噬系统转录组特征